delta1-piperideine-2-carboxylate reductase
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space)	domain 2 is binding domain(fixed in space)

Sequence

__________________________________________________   2cwf(A) : ***TQTVSYPQLIDLLRRIFVVHGTSPEVADVLAENCASAQRDGSHSHGI           :                                                      1wtj(B) : DQPTQTVSYPQLIDLLRRIFVVHGTSPEVADVLAENCASAQRDGSHSHGI             __________________________________________________             __________________________________________________   2cwf(A) : FRIPGYLSSLASGWVDGKAVPVVEDVGAAFVRVDACNGFAQPALAAARSL           :                                                      1wtj(B) : FRIPGYLSSLASGWVDGKAVPVVEDVGAAFVRVDACNGFAQPALAAARSL             __________________________________________________             __________________________________________________   2cwf(A) : LIDKARSAGVAILAIRGSHHFAALWPDVEPFAEQGLVALSMVNSMTCVVP           :                                                      1wtj(B) : LIDKARSAGVAILAIRGSHHFAALWPDVEPFAEQGLVALSMVNSMTCVVP             __________________________________________________             ______________________________189_________________   2cwf(A) : HGARQPLFGTNPIAFGAPRAGGEPIVFDLATSAIAHGDVQIAAREGRLLP           :                                                      1wtj(B) : HGARQPLFGTNPIAFGAPRAGGEPIVFDLATSAIAHGDVQIAAREGRLLP             ______________________________189_________________             ____________________229___________________________   2cwf(A) : AGMGVDRDGLPTQEPRAILDGGALLPFGGHKGSALSMMVELLAAGLTGGN           :                                                      1wtj(B) : AGMGVDRDGLPTQEPRAILDGGALLPFGGHKGSALSMMVELLAAGLTGGN             ____________________229___________________________             __________________________________________________   2cwf(A) : FSFEFDWSKHPGAQTPWTGQLLIVIDPDKGAGQHFAQRSEELVRQLHGVG           :                                                      1wtj(B) : FSFEFDWSKHPGAQTPWTGQLLIVIDPDKGAGQHFAQRSEELVRQLHGVG             __________________________________________________             _____________________________________                2cwf(A) : QERLPGDRRYLERARSMAHGIVIAQADLERLQELA**                        :                                                      1wtj(B) : QERLPGDRRYLERARSMAHGIVIAQADLERLQELAGH                          _____________________________________

Details

Property   Value  Conformer 1 2cwf(A)  Conformer 2 1wtj(B)  Radius gyration for conformer 1 19.92 A  Radius gyration for conformer 2 19.72 A  EC Number 1.1.1.154   Click here to see the DynDom results or the famliy  Trigger ligands NDP2510  Trigger ligands in which conformation Conformation  1  Conformaton with trigger ligands is compact No  Spanning ligands Yes  Residues in enzyme contacting ligands ALA128  ALA129  ALA186  ALA191  ARG309  ARG314  ARG315  ASP184  ASP313  GLY312  HIS126  HIS54  LEU130  LEU185  PHE183  PRO168  PRO311  SER150  THR166  VAL182   Residues in extended bending regions contacting ligands ALA186  ALA191   Residues in extended bending regions making H-bonds or salt-bridges with ligands ALA186    Residues in extended bending regions with an H-bond between its main chain and ligands ALA186  Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT