D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PHOSPHOGL
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1psd(A) : **EKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDA 
         :                                                    
 1yba(D) : SLEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDA 
           __________________________________________________ 

           ________________________________________________10 
 1psd(A) : HFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNA 
         :                                                    
 1yba(D) : HFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNA 
           ________________________________________________10 

           5_________________________________________________ 
 1psd(A) : PFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKL 
         :                                                    
 1yba(D) : PFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKL 
           5_________________________________________________ 

           __________________________________________________ 
 1psd(A) : GIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQVQHLSDLLNMS 
         :                                                    
 1yba(D) : GIIGYGHIGTQLGILAESLG-yVYFYDIENKLPLGNATQVQHLSDLLN-s 
           __________________________________________________ 

           __________________________________________________ 
 1psd(A) : DVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALA 
         :                                                    
 1yba(D) : DVVSLHVPENPSTKN--gAKEISL-kPGSLLINASRGTVVDIPALCDALA 
           __________________________________________________ 

           _________________________________________298______ 
 1psd(A) : SKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 
         :                                                    
 1yba(D) : SKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 
           _________________________________________298______ 

           __________________________________________________ 
 1psd(A) : GLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTAL 
         :                                                    
 1yba(D) : GLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRL-hIHENRPGVLTAL 
           __________________________________________________ 

           __________________________________________________ 
 1psd(A) : NKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTI 
         :                                                    
 1yba(D) : NKIFAEQGVNIAAQYLQTSAQ-gYVVIDIEADEDVAEKALQA-kAIPGTI 
           __________________________________________________ 

           ______                                             
 1psd(A) : RARLLY                                             
         :                                                    
 1yba(D) : RARLLY                                             
           ______                                             

Details

  Property   Value
 Conformer 1 1psd(A)
 Conformer 2 1yba(D)
 Radius gyration for conformer 1 26.31 A
 Radius gyration for conformer 2 26.31 A
 EC Number 1.1.1.95  
Click here to see the DynDom results or the famliy
 Trigger ligands AKG3
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact No
 Spanning ligands Yes
 Residues in enzyme contacting ligands ARG60  ASN108  CYS83  SER61 
 Residues in extended bending regions contacting ligands ASN108 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT