farnesyl pyrophosphate synthase
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           ___________13_____________________________44______ 
 1yhk(A) : MASMERFLSVYDEVQAFLLDQLQSKYEIDPNRARYLRIMMDTTCLGGKYF 
         :                                                    
 1yhl(A) : MASMERFLSVYDEVQAFLLDQLQSKYEIDPNRARYLRIMMDTTCLGGKYF 
           ___________13_____________________________44______ 

           ___________________________________87_____________ 
 1yhk(A) : RGMTVVNVAEGFLAVTQHDEATKERILHDACVGGWMIEFLQAHYLVEDDI 
         :                                                    
 1yhl(A) : RGMTVVNVAEGFLAVTQHDEATKERILHDACVGGWMIEFLQAHYLVEDDI 
           ___________________________________87_____________ 

           _______________________________134________________ 
 1yhk(A) : MDGSVMRRGKPCWYRFPGVTTQCAINDGIILKSWTQIMAWHYFADRPFLK 
         :                                                    
 1yhl(A) : MDGSVMRRGKPCWYRFPGVTTQCAINDGIILKSWTQIMAWHYFADRPFLK 
           _______________________________134________________ 

           __________________________________________________ 
 1yhk(A) : DLLCLFQKVDYATAVGQMYDVTSMCDSNKLDPEVAQPMTTDFAEFTPAIY 
         :                                                    
 1yhl(A) : DLLCLFQKVDYATAVGQMYDVTSMCDSNKLDPEVAQPMTTDFAEFTPAIY 
           __________________________________________________ 

           __________________________________________________ 
 1yhk(A) : KRIVKYKTTFYTYLLPLVMGLFVSEAAASVEMNLVERVAHLIGEYFQVQD 
         :                                                    
 1yhl(A) : KRIVKYKTTFYTYLLPLVMGLFVSEAAASVEMNLVERVAHLIGEYFQVQD 
           __________________________________________________ 

           __________________________________________________ 
 1yhk(A) : DVMDCFTPPEQLGKVGTDIEDAKCSWLAVTFLGKANAAQVAEFKANYGDK 
         :                                                    
 1yhl(A) : DVMDCFTPPEQLGKVGTDIEDAKCSWLAVTFLGKANAAQVAEFKANYGDK 
           __________________________________________________ 

           __________________________________________________ 
 1yhk(A) : DPAKVAVVKRLYSEANLQADFAAYEAEVVREVESLIEQLKVKSPTFAESV 
         :                                                    
 1yhl(A) : DPAKVAVVKRLYSEANLQADFAAYEAEVVREVESLIEQLKVKSPTFAESV 
           __________________________________________________ 

           ____________                                       
 1yhk(A) : AVVWEKTHKR**                                       
         :                                                    
 1yhl(A) : AVVWEKTHKRKK                                       
           ____________                                       

Details

  Property   Value
 Conformer 1 1yhk(A)
 Conformer 2 1yhl(A)
 Radius gyration for conformer 1 21.66 A
 Radius gyration for conformer 2 21.4 A
 EC Number 2.5.1.10  
Click here to see the DynDom results or the famliy
 Trigger ligands DMA1301
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ARG108  ARG51  GLN91  GLY47  LEU95  LYS264  LYS362  LYS48  PHE246  PHE50  TYR211  TYR49 
 Residues in extended bending regions contacting ligands GLN91  GLY47  LYS48 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands GLN91  LYS48 
  Residues in extended bending regions with an H-bond between its main chain and ligands LYS48 
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT