mRNA capping enzyme alpha subunit
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1sjs    : ESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDA 
         :                                                    
 1hj6(A) : *SKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDA 
           __________________________________________________ 

           __________________________________________________ 
 1sjs    : AVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKG 
         :                                                    
 1hj6(A) : AVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKG 
           __________________________________________________ 

           _____________________125_____133__________________ 
 1sjs    : PLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVI 
         :                                                    
 1hj6(A) : PLTTPVGGGIRELNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVI 
           _____________________125_____133__________________ 

           __________________________________________________ 
 1sjs    : FRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC 
         :                                                    
 1hj6(A) : FRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC 
           __________________________________________________ 

           __________________________________________________ 
 1sjs    : SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 
         :                                                    
 1hj6(A) : SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 
           __________________________________________________ 

           __________________________________________________ 
 1sjs    : EFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIAC 
         :                                                    
 1hj6(A) : EFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIAC 
           __________________________________________________ 

           ________________320_______________________________ 
 1sjs    : MNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKV 
         :                                                    
 1hj6(A) : MNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKV 
           ________________320_______________________________ 

           __________________________________________________ 
 1sjs    : NPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAK 
         :                                                    
 1hj6(A) : NPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAK 
           __________________________________________________ 

           _______________                                    
 1sjs    : LLKCSEFGDAIIENM                                    
         :                                                    
 1hj6(A) : LLKCSEFGDAIIENM                                    
           _______________                                    

Details

  Property   Value
 Conformer 1 1p16(A)
 Conformer 2 1p16(B)
 Radius gyration for conformer 1 24.62 A
 Radius gyration for conformer 2 24.77 A
 EC Number 2.7.7.50  
Click here to see the DynDom results or the famliy
 Trigger ligands GTP5001
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact No
 Spanning ligands No
 Residues in enzyme contacting ligands ARG72  CYS65  GLN44  GLU126  ILE223  LEU239  LYS197  LYS241  LYS243  LYS67  PHE144  PRO45  SER43 
 Residues in extended bending regions contacting ligands LYS241  LYS243 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands LYS241  LYS243 
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT