DIAMINOPIMELIC ACID DEHYDROGENASE
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space)	domain 2 is binding domain(fixed in space)

Sequence

__________________________________________________   1f06(A) : MTNIRVAIVGYGNLGRSVEKLIAKQPDMDLVGIFSRRATLDTKTPVFDVA           :                                                      1f06(B) : MTNIRVAIVGYGNLGRSVEKLIAKQPDMDLVGIFSRRATLDTKTPVFDVA             __________________________________________________             __________________________________________________   1f06(A) : DVDKHADDVDVLFLCMGSATDIPEQAPKFAQFACTVDTYDNHRDIPRHRQ           :                                                      1f06(B) : DVDKHADDVDVLFLCMGSATDIPEQAPKFAQFACTVDTYDNHRDIPRHRQ             __________________________________________________             ______________________________________141_________   1f06(A) : VMNEAATAAGNVALVSTGWDPGMFSINRVYAAAVLAEHQQHTFWGPGLSQ           :                                                      1f06(B) : VMNEAATAAGNVALVSTGWDPGMFSINRVYAAAVLAEHQQHTFWGPGLSQ             ______________________________________641_________             _________________170______________________________   1f06(A) : GHSDALRRIPGVQKAVQYTLPSEDALEKARRGEAGDLTGKQTHKRQCFVV           :                                                      1f06(B) : GHSDALRRIPGVQKAVQYTLPSEDALEKARRGEAGDLTGKQTHKRQCFVV             _________________670______________________________             ___________________________________238____________   1f06(A) : ADAADHERIENDIRTMPDYFVGYEVEVNFIDEATFDSEHTGMPHGGHVIT           :                                                      1f06(B) : ADAADHERIENDIRTMPDYFVGYEVEVNFIDEATFDSEHTGMPHGGHVIT             ___________________________________738____________             __________________________________________________   1f06(A) : TGDTGGFNHTVEYILKLDRNPDFTASSQIAFGRAAHRMKQQGQSGAFTVL           :                                                      1f06(B) : TGDTGGFNHTVEYILKLDRNPDFTASSQIAFGRAAHRMKQQGQSGAFTVL             __________________________________________________             ____________________                                 1f06(A) : EVAPYLLSPENLDDLIARDV                                         :                                                      1f06(B) : EVAPYLLSPENLDDLIARDV                                           ____________________

Details

Property   Value  Conformer 1 1f06(A)  Conformer 2 1f06(B)  Radius gyration for conformer 1 21.99 A  Radius gyration for conformer 2 20.62 A  EC Number 1.4.1.16   Click here to see the DynDom results or the famliy  Trigger ligands 2NP950 NDP901  Trigger ligands in which conformation Conformation  2  Conformaton with trigger ligands is compact Yes  Spanning ligands Yes  Residues in enzyme contacting ligands ARG536  ARG537  ARG657  ARG695  ASN513  ASN770  ASP590  ASP620  ASP654  CYS565  GLN650  GLY510  GLY512  GLY567  GLY618  GLY651  HIS652  HIS744  LEU514  LEU648  MET566  PRO621  SER535  SER568  SER649  THR588  THR617  THR669  THR774  TRP619  TRP644  TYR511   Residues in extended bending regions contacting ligands HIS744  LEU648  SER649  THR669  TRP644   Residues in extended bending regions making H-bonds or salt-bridges with ligands HIS744  SER649  THR669    Residues in extended bending regions with an H-bond between its main chain and ligands Null Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT