Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)







  Property   Value
 Conformer 1 1kam(B)
 Conformer 2 1kaq(A)
 Radius gyration for conformer 1 17.17 A
 Radius gyration for conformer 2 15.95 A
 EC Number  
Click here to see the DynDom results or the famliy
 Trigger ligands DND601
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ARG133  ASN39  ASP108  GLY106  GLY8  GLY9  HIS15  HIS18  HIS44  LYS45  MET109  MET21  PHE11  PHE152  PHE7  PRO43  THR10  THR85  TRP116  TYR117  TYR84  VAL154 
 Residues in extended bending regions contacting ligands GLY106 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT