PHOSPHOSERINE PHOSPHATASE (PSP)
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space)	domain 2 is binding domain(fixed in space)

Sequence

_________________________529____________________55   1l7o(B) : **KKKLILFNFDSTLVNNETIDEIAREAGVEEEVKKITKEAeGKLNFEQS           :                                                      1l7p(B) : EKKKKLILFNFDSTLVNNETIDEIAREAGVEEEVKKITKEAeGKLNFEQS             _________________________529____________________55             3_________________________________________________   1l7o(B) : LRKRVSLLKDLPIEKVEKAIKRITPTEGAEETIKELKNRGYVVAVVSGGF           :                                                      1l7p(B) : LRKRVSLLKDLPIEKVEKAIKRITPTEGAEETIKELKNRGYVVAVVSGGF             3_________________________________________________             __________________________________________________   1l7o(B) : DIAVNKIKEKLGLDYAFANRLIVKDGKLTGDVEGEVLKENAKGEILEKIA           :                                                      1l7p(B) : DIAVNKIKEKLGLDYAFANRLIVKDGKLTGDVEGEVLKENAKGEILEKIA             __________________________________________________             __________________________________________________   1l7o(B) : KIEGINLEDTVAVGDGANDISfKKAGLKIAFCAKPILKEKADICIEKRDL           :                                                      1l7p(B) : KIEGINLEDTVAVGDGANDISfKKAGLKIAFCAKPILKEKADICIEKRDL             __________________________________________________             ________                                             1l7o(B) : REILKYIK                                                     :                                                      1l7p(B) : REILKYIK                                                       ________

Details

Property   Value  Conformer 1 1l7o(B)  Conformer 2 1l7p(B)  Radius gyration for conformer 1 16.99 A  Radius gyration for conformer 2 16.69 A  EC Number 3.1.3.3   Click here to see the DynDom results or the famliy  Trigger ligands SEP270  Trigger ligands in which conformation Conformation  2  Conformaton with trigger ligands is compact Yes  Spanning ligands Yes  Residues in enzyme contacting ligands ARG556  ASN511  ASN670  ASP513  GLU520  GLY600  GLY601  LEU553  LYS644  PHE512  PHE549  SER599   Residues in extended bending regions contacting ligands ARG556  LEU553   Residues in extended bending regions making H-bonds or salt-bridges with ligands Null   Residues in extended bending regions with an H-bond between its main chain and ligands Null Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT