phosphoenolpyruvate carboxykinase [ATP]
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space)	domain 2 is binding domain(fixed in space)

Sequence

__________________________________________________   1ytm(B) : SLSESLAKYGITGATNIVHNPSHEELFAAETQASLEGFEKGTVTEMGAVN           :                                                      1yvy(A) : SLSESLAKYGITGATNIVHNPSHEELFAAETQASLEGFEKGTVTEMGAVN             __________________________________________________             __________________________________________________   1ytm(B) : VMTGVYTGRSPKDKFIVKNEASKEIWWTSDEFKNDNKPVTEEAWAQLKAL           :                                                      1yvy(A) : VMTGVYTGRSPKDKFIVKNEASKEIWWTSDEFKNDNKPVTEEAWAQLKAL             __________________________________________________             __________________________________________________   1ytm(B) : AGKELSNKPLYVVDLFCGANENTRLKIRFVMEVAWQAHFVTNMFIRPTEE           :                                                      1yvy(A) : AGKELSNKPLYVVDLFCGANENTRLKIRFVMEVAWQAHFVTNMFIRPTEE             __________________________________________________             __________________________________________________   1ytm(B) : ELKGFEPDFVVLNASKAKVENFKELGLNSETAVVFNLAEKMQIILNTWYG           :                                                      1yvy(A) : ELKGFEPDFVVLNASKAKVENFKELGLNSETAVVFNLAEKMQIILNTWYG             __________________________________________________             __________________________________1239____1247____   1ytm(B) : GEMKKGMFSMMNFYLPLQGIAAMHCSANTDLEGKNTAIFFGLSGTGKTTL           :                                                      1yvy(A) : GEMKKGMFSMMNFYLPLQGIAAMHCSANTDLEGKNTAIFFGLSGTGKTTL             ___________________________________239_____247____             __________________________________________________   1ytm(B) : STDPKRLLIGDDEHGWDDDGVFNFEGGCYAKVINLSKENEPDIWGAIKRN           :                                                      1yvy(A) : STDPKRLLIGDDEHGWDDDGVFNFEGGCYAKVINLSKENEPDIWGAIKRN             __________________________________________________             ____________________________________________1349__   1ytm(B) : ALLENVTVDANGKVDFADKSVTENTRVSYPIFHIKNIVKPVSKAPAAKRV           :                                                      1yvy(A) : ALLENVTVDANGKVDFADKSVTENTRVSYPIFHIKNIVKPVSKAPAAKRV             _____________________________________________349__             _____________________________________________1400_   1ytm(B) : IFLSADAFGVLPPVSILSKEQTKYYFLSGFTAKLAGTERGITEPTPTFSS           :                                                      1yvy(A) : IFLSADAFGVLPPVSILSKEQTKYYFLSGFTAK----------pTPTFSS             ______________________________________________400_             ________________________1429______________________   1ytm(B) : CFGAAFLTLPPTKYAEVLVKRMEASGAKAYLVNTGWNGTGKRISIKDTRG           :                                                      1yvy(A) : CFGAAFLTLPPTKYAEVLVKRMEASGAKAYLVNTGWNGTGKRISIKDTRG             _________________________429______________________             __________________________________________________   1ytm(B) : IIDAILDGSIDTANTATIPYFNFTVPTELKGVDTKILDPRNTYADASEWE           :                                                      1yvy(A) : IIDAILDGSIDTANTATIPYFNFTVPTELKGVDTKILDPRNTYADASEWE             __________________________________________________             _________________                                    1ytm(B) : VKAKDLAERFQKNFKKF                                            :                                                      1yvy(A) : VKAKDLAERFQKNFKKF                                              _________________

Details

Property   Value  Conformer 1 1ytm(B)  Conformer 2 1yvy(A)  Radius gyration for conformer 1 22.65 A  Radius gyration for conformer 2 22.92 A  EC Number 4.1.1.49   Click here to see the DynDom results or the famliy  Trigger ligands OXD1543 ATP1541  Trigger ligands in which conformation Conformation  1  Conformaton with trigger ligands is compact Yes  Spanning ligands Yes  Residues in enzyme contacting ligands ARG1060  ARG1327  ARG1443  ASP1263  GLY1245  GLY1247  HIS1225  ILE1444  ILE1446  LEU1243  LYS1206  LYS1248  LYS1282  PHE1407  SER1244  SER1445  THR1246  THR1249  THR1250  THR1435  THR1449  TYR1200  TYR1280   Residues in extended bending regions contacting ligands GLY1245  GLY1247  LEU1243  LYS1248  SER1244  THR1246  THR1249  THR1250   Residues in extended bending regions making H-bonds or salt-bridges with ligands GLY1245  GLY1247  LYS1248  SER1244  THR1246  THR1249  THR1250    Residues in extended bending regions with an H-bond between its main chain and ligands GLY1245  GLY1247  LYS1248  THR1246  THR1249  THR1250  Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT