Sarcoplasmic/endoplasmic reticulum calcium AT
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space)	domain 2 is binding domain(fixed in space)

Sequence

__________________________________________________   1wpg(C) : MEAAHSKSTEECLAYFGVSETTGLTPDQVKRHLEKYGHNELPAEEGKSLW           :                                                      2eau(A) : MEAAHSKSTEECLAYFGVSETTGLTPDQVKRHLEKYGHNELPAEEGKSLW             __________________________________________________             __________________________________________________   1wpg(C) : ELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILIA           :                                                      2eau(A) : ELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILIA             __________________________________________________             __________________________________________________   1wpg(C) : NAIVGVWQERNAENAIEALKEYEPEMGKVYRADRKSVQRIKARDIVPGDI           :                                                      2eau(A) : NAIVGVWQERNAENAIEALKEYEPEMGKVYRADRKSVQRIKARDIVPGDI             __________________________________________________             __________________________________________________   1wpg(C) : VEVAVGDKVPADIRILSIKSTTLRVDQSILTGESVSVIKHTEPVPDPRAV           :                                                      2eau(A) : VEVAVGDKVPADIRILSIKSTTLRVDQSILTGESVSVIKHTEPVPDPRAV             __________________________________________________             __________________________________________________   1wpg(C) : NQDKKNMLFSGTNIAAGKALGIVATTGVSTEIGKIRDQMAATEQDKTPLQ           :                                                      2eau(A) : NQDKKNMLFSGTNIAAGKALGIVATTGVSTEIGKIRDQMAATEQDKTPLQ             __________________________________________________             __________________________________________________   1wpg(C) : QKLDEFGEQLSKVISLICVAVWLINIGHFNDPVHGGSWIRGAIYYFKIAV           :                                                      2eau(A) : QKLDEFGEQLSKVISLICVAVWLINIGHFNDPVHGGSWIRGAIYYFKIAV             __________________________________________________             __________________________________________________   1wpg(C) : ALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICS           :                                                      2eau(A) : ALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICS             __________________________________________________             ________361_______________________________________   1wpg(C) : DKTGTLTTNQMSVCKMFIIDKVDGDFCSLNEFSITGSTYAPEGEVLKNDK           :                                                      2eau(A) : DKTGTLTTNQMSVCKMFIIDKVDGDFCSLNEFSITGSTYAPEGEVLKNDK             ________361_______________________________________             __________________________________________________   1wpg(C) : PIRSGQFDGLVELATICALCNDSSLDFNETKGVYEKVGEATETALTTLVE           :                                                      2eau(A) : PIRSGQFDGLVELATICALCNDSSLDFNETKGVYEKVGEATETALTTLVE             __________________________________________________             __________________________________________________   1wpg(C) : KMNVFNTEVRNLSKVERANACNSVIRQLMKKEFTLEFSRDRKSMSVYCSP           :                                                      2eau(A) : KMNVFNTEVRNLSKVERANACNSVIRQLMKKEFTLEFSRDRKSMSVYCSP             __________________________________________________             __________________________________________________   1wpg(C) : AKSSRAAVGNKMFVKGAPEGVIDRCNYVRVGTTRVPMTGPVKEKILSVIK           :                                                      2eau(A) : AKSSRAAVGNKMFVKGAPEGVIDRCNYVRVGTTRVPMTGPVKEKILSVIK             __________________________________________________             ______________________________________________599_   1wpg(C) : EWGTGRDTLRCLALATRDTPPKREEMVLDDSSRFMEYETDLTFVGVVGML           :                                                      2eau(A) : EWGTGRDTLRCLALATRDTPPKREEMVLDDSSRFMEYETDLTFVGVVGML             ______________________________________________599_             __________________________________________________   1wpg(C) : DPPRKEVMGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFGENEEVAD           :                                                      2eau(A) : DPPRKEVMGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFGENEEVAD             __________________________________________________             __________________________________________________   1wpg(C) : RAYTGREFDDLPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAM           :                                                      2eau(A) : RAYTGREFDDLPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAM             __________________________________________________             __________________________________________________   1wpg(C) : TGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEG           :                                                      2eau(A) : TGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEG             __________________________________________________             __________________________________________________   1wpg(C) : RAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLPEALIPVQLLWVNLVTD           :                                                      2eau(A) : RAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLPEALIPVQLLWVNLVTD             __________________________________________________             __________________________________________________   1wpg(C) : GLPATALGFNPPDLDIMDRPPRSPKEPLISGWLFFRYMAIGGYVGAATVG           :                                                      2eau(A) : GLPATALGFNPPDLDIMDRPPRSPKEPLISGWLFFRYMAIGGYVGAATVG             __________________________________________________             __________________________________________________   1wpg(C) : AAAWWFMYAEDGPGVTYHQLTHFMQCTEDHPHFEGLDCEIFEAPEPMTMA           :                                                      2eau(A) : AAAWWFMYAEDGPGVTYHQLTHFMQCTEDHPHFEGLDCEIFEAPEPMTMA             __________________________________________________             __________________________________________________   1wpg(C) : LSVLVTIEMCNALNSLSENQSLMRMPPWVNIWLLGSICLSMSLHFLILYV           :                                                      2eau(A) : LSVLVTIEMCNALNSLSENQSLMRMPPWVNIWLLGSICLSMSLHFLILYV             __________________________________________________             ____________________________________________         1wpg(C) : DPLPMIFKLKALDLTQWLMVLKISLPVIGLDEILKFIARNYLEG                 :                                                      2eau(A) : DPLPMIFKLKALDLTQWLMVLKISLPVIGLDEILKFIARNYLEG                   ____________________________________________

Details

Property   Value  Conformer 1 1wpg(C)  Conformer 2 2eau(A)  Radius gyration for conformer 1 39.1 A  Radius gyration for conformer 2 38.86 A  EC Number 3.6.3.8   Click here to see the DynDom results or the famliy  Trigger ligands ADP1202  Trigger ligands in which conformation Conformation  1  Conformaton with trigger ligands is compact No  Spanning ligands Yes  Residues in enzyme contacting ligands ALA517  GLY516  ILE188  LEU562  LYS205  LYS515  MET494  PHE487   Residues in extended bending regions contacting ligands Null  Residues in extended bending regions making H-bonds or salt-bridges with ligands Null   Residues in extended bending regions with an H-bond between its main chain and ligands Null Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT