UDP-N-acetylglucosamine 2-epimerase
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space)	domain 2 is binding domain(fixed in space)

Sequence

__________________________________________________   1vgv(D) : KVLTVFGTRPEAIKaPLVHALAKDPFFEAKVCVTAQHRElDQVLKLFSIV           :                                                      1vgv(B) : KVLTVFGTRPEAIKaPLVHALAKDPFFEAKVCVTAQHRElDQVLKLFSIV             __________________________________________________             __________________________________________________   1vgv(D) : PDYDLNIqPGQGLTEITCRILEGLKPILAEFKPDVVLVHGDTTTTLATSL           :                                                      1vgv(B) : PDYDLNIq---GLTEITCRILEGLKPILAEFKPDVVLVHGDTTTTLATSL             __________________________________________________             __________________________________________________   1vgv(D) : AAFYQRIPVGHVEAGLRTGDLYSPWPEEANRTLTGHLAyHFSPTETSRQN           :                                                      1vgv(B) : AAFYQRIPVGHVEAGLRTGDLYSPWPEEANRTLTGHLAyHFSPTETSRQN             __________________________________________________             ______________________180_________________________   1vgv(D) : LLRENVADSRIFITGNTVIDALLWVRDQVsSDKLRSELAANYPFIDPDKK           :                                                      1vgv(B) : LLRENVADSRIFITGNTVIDALLWVRDQVsSDKLRSELAANYPFIDPDKK             ______________________180_________________________             __________________________________________________   1vgv(D) : iLVTGHRRESFGRGFEEICHALADIATTHQDIQIVYPVHLNPNVREPVNR           :                                                      1vgv(B) : iLVTGHRRESFGRGFEEICHALADIATTHQDIQIVYPVHLNPNVREPVNR             __________________________________________________             __________________________________________________   1vgv(D) : ILGHVKNVILIDPQEYLPFVWLnHAWLILTDSGGIQEEAPSLGKPVLVrD           :                                                      1vgv(B) : ILGHVKNVILIDPQEYLPFVWLnHAWLILTDSGGIQEEAPSLGKPVLVrD             __________________________________________________             __________________________________________355_____   1vgv(D) : TTERPEAVTAGTVRLVGTDKQRIVEEVTRLLKDENEYQAsRAHNPYGDGQ           :                                                      1vgv(B) : TTERPEAVTAGTVRLVGTDKQRIVEEVTRLLKDENEYQAsRAHNPYGDGQ             __________________________________________355_____             ________________                                     1vgv(D) : ACSRILEALKNNRI**                                             :                                                      1vgv(B) : ACSRILEALKNNRISL                                               ________________

Details

Property   Value  Conformer 1 1vgv(D)  Conformer 2 1vgv(B)  Radius gyration for conformer 1 21.86 A  Radius gyration for conformer 2 21.11 A  EC Number 5.1.3.14   Click here to see the DynDom results or the famliy  Trigger ligands UD21  Trigger ligands in which conformation Conformation  2  Conformaton with trigger ligands is compact Yes  Spanning ligands Yes  Residues in enzyme contacting ligands ARG10  ARG135  ARG313  ASP95  GLN271  GLU117  GLU12  GLU131  GLU296  GLY291  GLY292  HIS213  HIS93  ILE14  LYS15  PHE276  PRO11  SER290  THR211  THR9  THR96  TYR273   Residues in extended bending regions contacting ligands Null  Residues in extended bending regions making H-bonds or salt-bridges with ligands Null   Residues in extended bending regions with an H-bond between its main chain and ligands Null Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT