ASPARTYL-TRNA SYNTHETASE
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Jmol._Canvas2D (Jmol) "jmolApplet2"[x]

Domain Movement

Jmol._Canvas2D (Jmol) "jmolApplet0"[x]	Jmol._Canvas2D (Jmol) "jmolApplet1"[x]
domain 1 is binding domain(fixed in space)	domain 2 is binding domain(fixed in space)

Sequence

__________________________________________________   2o3s(B) : FWRQTWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFI           :                                                      2i67(B) : RWRQTWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFI             __________________________________________________             ________________________121__________________142__   2o3s(B) : SKHPCDITEEDYQPLMKLGTQTVPCNKILLWSRIKDLAHQFTQVQRDMFT           :                                                      2i67(B) : SKHPCDITEEDYQPLMKLGTQTVPCNKILLWSRIKDLAHQFTQVQRDMFT             ________________________121__________________142__             __________________________________________________   2o3s(B) : LEDTLLGYLADDLTWCGEFDTSKINYQSCPDWRKDCSNNPVSVFWKTVSR           :                                                      2i67(B) : LEDTLLGYLADDLTWCGEFDTSKINYQSCPDWRKDCSNNPVSVFWKTVSR             __________________________________________________             ______203_______________221____________236________   2o3s(B) : RFAEAACDVVHVMLDGSRSKIFDKDSTFGSVGVHNLQPEKVQTLEAWVIH           :                                                      2i67(B) : RFAEAACDVVHVMLDGSRSKIFDKDSTFGSVEVHNLQPEKVQTLEAWVIH             ______203_______________221____________236________             __________________________________________________   2o3s(B) : GGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKFLQCVKNPEDS           :                                                      2i67(B) : GGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKFLQCVKNPE**             __________________________________________________             __                                                   2o3s(B) : SC                                                           :                                                      2i67(B) : **                                                             __

Details

Property   Value  Conformer 1 1g51(B)  Conformer 2 1efw(A)  Radius gyration for conformer 1 29.58 A  Radius gyration for conformer 2 29.77 A  EC Number 6.1.1.12   Click here to see the DynDom results or the famliy  Trigger ligands AMP800  Trigger ligands in which conformation Conformation  1  Conformaton with trigger ligands is compact Yes  Spanning ligands No  Residues in enzyme contacting ligands ALA1350  ALA1390  GLN1347  GLU1338  GLY1348  LEU1349  PHE1311  PHE1388  VAL1313  VAL1389   Residues in extended bending regions contacting ligands Null  Residues in extended bending regions making H-bonds or salt-bridges with ligands Null   Residues in extended bending regions with an H-bond between its main chain and ligands Null Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT