ADP-ribosyl cyclase 1
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space)	domain 2 is binding domain(fixed in space)

Sequence

__________________________________________________   2o3s(B) : FWRQTWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFI           :                                                      2i67(B) : RWRQTWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFI             __________________________________________________             ________________________121__________________142__   2o3s(B) : SKHPCDITEEDYQPLMKLGTQTVPCNKILLWSRIKDLAHQFTQVQRDMFT           :                                                      2i67(B) : SKHPCDITEEDYQPLMKLGTQTVPCNKILLWSRIKDLAHQFTQVQRDMFT             ________________________121__________________142__             __________________________________________________   2o3s(B) : LEDTLLGYLADDLTWCGEFDTSKINYQSCPDWRKDCSNNPVSVFWKTVSR           :                                                      2i67(B) : LEDTLLGYLADDLTWCGEFDTSKINYQSCPDWRKDCSNNPVSVFWKTVSR             __________________________________________________             ______203_______________221____________236________   2o3s(B) : RFAEAACDVVHVMLDGSRSKIFDKDSTFGSVGVHNLQPEKVQTLEAWVIH           :                                                      2i67(B) : RFAEAACDVVHVMLDGSRSKIFDKDSTFGSVEVHNLQPEKVQTLEAWVIH             ______203_______________221____________236________             __________________________________________________   2o3s(B) : GGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKFLQCVKNPEDS           :                                                      2i67(B) : GGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKFLQCVKNPE**             __________________________________________________             __                                                   2o3s(B) : SC                                                           :                                                      2i67(B) : **                                                             __

Details

Property   Value  Conformer 1 2o3s(B)  Conformer 2 2i67(B)  Radius gyration for conformer 1 19.82 A  Radius gyration for conformer 2 19.18 A  EC Number 3.2.2.5   Click here to see the DynDom results or the famliy  Trigger ligands APR302  Trigger ligands in which conformation Conformation  2  Conformaton with trigger ligands is compact Yes  Spanning ligands Yes  Residues in enzyme contacting ligands ARG212  ASP155  ASP156  GLU146  LYS129  THR221  TRP125  TRP189  VAL185   Residues in extended bending regions contacting ligands GLU146  THR221  TRP125   Residues in extended bending regions making H-bonds or salt-bridges with ligands GLU146  THR221    Residues in extended bending regions with an H-bond between its main chain and ligands Null Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT