alcohol dehydrogenase, iron-containing
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space)	domain 2 is binding domain(fixed in space)

Sequence

__________________________________________________   1o2d(B) : HHVWEFYpTDVFFGEKILEKRGNIIDLLGKRALVVTGKSSSKKNGSLDDL           :                                                      1o2d(A) : **VWEFYpTDVFFGEKILEKRGNIIDLLGKRALVVTGKSSSKKNGSLDDL             __________________________________________________             __________________________________________________   1o2d(B) : KKLLDETEISYEIFDEVEENPSFDNVkAVERYRNDSFDFVVGLGGGSPdF           :                                                      1o2d(A) : KKLLDETEISYEIFDEVEENPSFDNVkAVERYRNDSFDFVVGLGGGSPdF             __________________________________________________             __________________________________________________   1o2d(B) : AKAVAVLLKEKDLSVEDLYDREKVKHWLPVVEIPTTAGTGSEVTPYSILT           :                                                      1o2d(A) : AKAVAVLLKEKDLSVEDLYDREKVKHWLPVVEIPTTAGTGSEVTPYSILT             __________________________________________________             _________________________________________197__202_   1o2d(B) : DPEGNKRGCTLfPVYAFLDPRYTYSsDELTLSTGVDALSHAVEGYLSRKS           :                                                      1o2d(A) : DPEGNKRGCTLfPVYAFLDPRYTYSsDELTLSTGVDALSHAVEGYLSRKS             _________________________________________197__202_             ___________________________________________252__25   1o2d(B) : TPPSDALAIEAkIIHRNLPKAIEGNREARKKfVASCLAGvIAQTGTTLAH           :                                                      1o2d(A) : TPPSDALAIEAkIIHRNLPKAIEGNREARKKfVASCLAGvIAQTGTTLAH             ___________________________________________252__25             7____264______273________________________________3   1o2d(B) : ALGYPLTTEKGIKHGKATGvLPFVeVkEEIPEKVDTVNHIFGGSLLKFLK           :                                                      1o2d(A) : ALGYPLTTEKGIKHGKATGvLPFVeVkEEIPEKVDTVNHIFGGSLLKFLK             7____264______273________________________________3             11____318______________335_339____________________   1o2d(B) : ELGLYEKVAVSSEELEKWVEKGSRAKHLKNTPGTFTPEKIRNIYREALG*           :                                                      1o2d(A) : ELGLYEKVAVSSEELEKWVEKGSRAKHLKNTPGTFTPEKIRNIYREALGV             11____318______________335_339____________________

Details

Property   Value  Conformer 1 1o2d(B)  Conformer 2 1o2d(A)  Radius gyration for conformer 1 20.03 A  Radius gyration for conformer 2 20.01 A  EC Number 1.1.1.1   Click here to see the DynDom results or the famliy  Trigger ligands FE900  Trigger ligands in which conformation Conformation  2  Conformaton with trigger ligands is compact Yes  Spanning ligands Yes  Residues in enzyme contacting ligands ASP189  HIS193  HIS256  HIS270   Residues in extended bending regions contacting ligands HIS256  HIS270   Residues in extended bending regions making H-bonds or salt-bridges with ligands HIS256    Residues in extended bending regions with an H-bond between its main chain and ligands Null Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT