ALPHA-TREHALOSE-PHOSPHATE SYNTHASE
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space)	domain 2 is binding domain(fixed in space)

Sequence

_____6_____________________________37_____________   1gz5(C) : SRLVVVSNRIAPPDEHAASAGGLAVGILGALKAAGGLWFGWSGETGNEDQ           :                                                      1uqt(B) : SRLVVVSNRIAPP------aGGLAVGILGALKAAGGLWFGWSGETGNEDQ             _____6_____________________________37_____________             _53______61_______________________________________   1gz5(C) : PLKKVKKGNITWASFNLSEQDLDEYYNQFSNAVLWPAFHYRLDLVQFQRP           :                                                      1uqt(B) : PLKKVKKGNITWASFNLSEQDLDEYYNQFSNAVLWPAFHYRLDLVQFQRP             _53______61_______________________________________             __________________________________________________   1gz5(C) : AWDGYLRVNALLADKLLPLLQDDDIIWIHDYHLLPFAHELRKRGVNNRIG           :                                                      1uqt(B) : AWDGYLRVNALLADKLLPLLQDDDIIWIHDYHLLPFAHELRKRGVNNRIG             __________________________________________________             __________________________________________________   1gz5(C) : FFLHIPFPTPEIFNALPTYDTLLEQLCDYDLLGFQTENDRLAFLDCLSNL           :                                                      1uqt(B) : FFLHIPFPTPEIFNALPTYDTLLEQLCDYDLLGFQTENDRLAFLDCLSNL             __________________________________________________             __________________________________________________   1gz5(C) : TRVTTRSAKSHTAWGKAFRTEVYPIGIEPKEIAKQAAGPLPPKLAQLKAE           :                                                      1uqt(B) : TRVTTRSAKSHTAWGKAFRTEVYPIGIEPKEIAKQAAGPLPPKLAQLKAE             __________________________________________________             __________________________________________________   1gz5(C) : LKNVQNIFSVERLDYSKGLPERFLAYEALLEKYPQHHGKIRYTQIAPTSR           :                                                      1uqt(B) : LKNVQNIFSVERLDYSKGLPERFLAYEALLEKYPQHHGKIRYTQIAPTSR             __________________________________________________             __________________________________________________   1gz5(C) : GDVQAYQDIRHQLENEAGRINGKYGQLGWTPLYYLNQHFDRKLL-kIFRY           :                                                      1uqt(B) : GDVQAYQDIRHQLENEAGRINGKYGQLGWTPLYYLNQHFDRKLLMKIFRY             __________________________________________________             __________________________________________________   1gz5(C) : SDVGLVTPLRDG-nLVAKEYVAAQDPANPGVLVLSQFAGAANELTSALIV           :                                                      1uqt(B) : SDVGLVTPLRDGMNLVAKEYVAAQDPANPGVLVLSQFAGAANELTSALIV             __________________________________________________             __________________________________________________   1gz5(C) : NPYDRDEVAAALDRALT-sLAERISRHAE-lDVIVKNDINHWQECFISDL           :                                                      1uqt(B) : NPYDRDEVAAALDRALTMSLAERISRHAEMLDVIVKNDINHWQECFISDL             __________________________________________________             ______                                               1gz5(C) : KQIVPR                                                       :                                                      1uqt(B) : KQIVPR                                                         ______

Details

Property   Value  Conformer 1 1gz5(C)  Conformer 2 1uqt(B)  Radius gyration for conformer 1 22.46 A  Radius gyration for conformer 2 22.78 A  EC Number 2.4.1.15   Click here to see the DynDom results or the famliy  Trigger ligands G6P901 UDP900  Trigger ligands in which conformation Conformation  1  Conformaton with trigger ligands is compact Yes  Spanning ligands Yes  Residues in enzyme contacting ligands ALA20  ARG262  ARG300  ARG341  ARG9  ASN364  ASP130  GLU369  GLY21  GLY22  HIS132  HIS154  HIS338  LEU23  LEU344  LEU365  LYS267  PHE339  PRO297  TRP85  TYR131  TYR76  VAL25  VAL260  VAL366   Residues in extended bending regions contacting ligands ALA20  ARG9  GLY21  GLY22  LEU23   Residues in extended bending regions making H-bonds or salt-bridges with ligands ARG9  GLY21  GLY22    Residues in extended bending regions with an H-bond between its main chain and ligands GLY21  GLY22  Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT