ATP synthase beta chain, mitochondrial
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space)	domain 2 is binding domain(fixed in space)

Sequence

__________________________________________________   2hld(N) : STPITGKVTAVIGAIVDVHFEQSELPAILNALEIKTPQGKLVLEVAQHLG           :                                                      2hld(M) : STPITGKVTAVIGAIVDVHFEQSELPAILNALEIKTPQGKLVLEVAQHLG             __________________________________________________             __________________________________________________   2hld(N) : ENTVRTIAMDGTEGLVRGEKVLDTGGPISVPVGRETLGRIINVIGEPIDE           :                                                      2hld(M) : ENTVRTIAMDGTEGLVRGEKVLDTGGPISVPVGRETLGRIINVIGEPIDE             __________________________________________________             _______________________131________________________   2hld(N) : RGPIKSKLRKPIHADPPSFAEQSTSAEILETGIKVVDLLAPYARGGKIGL           :                                                      2hld(M) : RGPIKSKLRKPIHADPPSFAEQSTSAEILETGIKVVDLLAPYARGGKIGL             _______________________131________________________             ______________172_________________________________   2hld(N) : FGGAGVGKTVFIQELINNIAKAHGGFSVFTGVGERTREGNDLYREMKETG           :                                                      2hld(M) : FGGAGVGKTVFIQELINNIAKAHGGFSVFTGVGERTREGNDLYREMKETG             ______________172_________________________________             __________________________________________________   2hld(N) : VINLEGESKVALVFGQMNEPPGARARVALTGLTIAEYFRDEEGQDVLLFI           :                                                      2hld(M) : VINLEGESKVALVFGQMNEPPGARARVALTGLTIAEYFRDEEGQDVLLFI             __________________________________________________             __________________________________________________   2hld(N) : DNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGLLQERITTTKKGSVT           :                                                      2hld(M) : DNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGLLQERITTTKKGSVT             __________________________________________________             ______________________330_________________________   2hld(N) : SVQAVYVPADDLTDPAPATTFAHLDATTVLSRGISELGIYPAVDPLDSKS           :                                                      2hld(M) : SVQAVYVPADDLTDPAPATTFAHLDATTVLSRGISELGIYPAVDPLDSKS             ______________________330_________________________             __________________________________________________   2hld(N) : RLLDAAVVGQEHYDVASKVQETLQTYKSLQDIIAILGMDELSEQDKLTVE           :                                                      2hld(M) : RLLDAAVVGQEHYDVASKVQETLQTYKSLQDIIAILGMDELSEQDKLTVE             __________________________________________________             __________________________________________________   2hld(N) : RARKIQRFLSQPFAVAEVFTGIPGKLVRLKDTVASFKAVLEGKYDNIPEH           :                                                      2hld(M) : RARKIQRFLSQPFAVAEVFTGIPGKLVRLKDTVASFKAVLEGKYDNIPEH             __________________________________________________             ____________________                                 2hld(N) : AFYMVGGIEDVVAKAEKLAA                                         :                                                      2hld(M) : AFYMVGGIEDVVAKAEKLAA                                           ____________________

Details

Property   Value  Conformer 1 2hld(N)  Conformer 2 2hld(M)  Radius gyration for conformer 1 25.37 A  Radius gyration for conformer 2 25.33 A  EC Number 3.6.3.14   Click here to see the DynDom results or the famliy  Trigger ligands PO4800  Trigger ligands in which conformation Conformation  1  Conformaton with trigger ligands is compact No  Spanning ligands Yes  Residues in enzyme contacting ligands ARG190  ARG260  ASN257  ASP256  LYS163   Residues in extended bending regions contacting ligands Null  Residues in extended bending regions making H-bonds or salt-bridges with ligands Null   Residues in extended bending regions with an H-bond between its main chain and ligands Null Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT