2-C-methyl-D-erythritol 2,4-cyclodiphosphate
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 2hld(N) : STPITGKVTAVIGAIVDVHFEQSELPAILNALEIKTPQGKLVLEVAQHLG 
         :                                                    
 2hld(M) : STPITGKVTAVIGAIVDVHFEQSELPAILNALEIKTPQGKLVLEVAQHLG 
           __________________________________________________ 

           __________________________________________________ 
 2hld(N) : ENTVRTIAMDGTEGLVRGEKVLDTGGPISVPVGRETLGRIINVIGEPIDE 
         :                                                    
 2hld(M) : ENTVRTIAMDGTEGLVRGEKVLDTGGPISVPVGRETLGRIINVIGEPIDE 
           __________________________________________________ 

           _______________________131________________________ 
 2hld(N) : RGPIKSKLRKPIHADPPSFAEQSTSAEILETGIKVVDLLAPYARGGKIGL 
         :                                                    
 2hld(M) : RGPIKSKLRKPIHADPPSFAEQSTSAEILETGIKVVDLLAPYARGGKIGL 
           _______________________131________________________ 

           ______________172_________________________________ 
 2hld(N) : FGGAGVGKTVFIQELINNIAKAHGGFSVFTGVGERTREGNDLYREMKETG 
         :                                                    
 2hld(M) : FGGAGVGKTVFIQELINNIAKAHGGFSVFTGVGERTREGNDLYREMKETG 
           ______________172_________________________________ 

           __________________________________________________ 
 2hld(N) : VINLEGESKVALVFGQMNEPPGARARVALTGLTIAEYFRDEEGQDVLLFI 
         :                                                    
 2hld(M) : VINLEGESKVALVFGQMNEPPGARARVALTGLTIAEYFRDEEGQDVLLFI 
           __________________________________________________ 

           __________________________________________________ 
 2hld(N) : DNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGLLQERITTTKKGSVT 
         :                                                    
 2hld(M) : DNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGLLQERITTTKKGSVT 
           __________________________________________________ 

           ______________________330_________________________ 
 2hld(N) : SVQAVYVPADDLTDPAPATTFAHLDATTVLSRGISELGIYPAVDPLDSKS 
         :                                                    
 2hld(M) : SVQAVYVPADDLTDPAPATTFAHLDATTVLSRGISELGIYPAVDPLDSKS 
           ______________________330_________________________ 

           __________________________________________________ 
 2hld(N) : RLLDAAVVGQEHYDVASKVQETLQTYKSLQDIIAILGMDELSEQDKLTVE 
         :                                                    
 2hld(M) : RLLDAAVVGQEHYDVASKVQETLQTYKSLQDIIAILGMDELSEQDKLTVE 
           __________________________________________________ 

           __________________________________________________ 
 2hld(N) : RARKIQRFLSQPFAVAEVFTGIPGKLVRLKDTVASFKAVLEGKYDNIPEH 
         :                                                    
 2hld(M) : RARKIQRFLSQPFAVAEVFTGIPGKLVRLKDTVASFKAVLEGKYDNIPEH 
           __________________________________________________ 

           ____________________                               
 2hld(N) : AFYMVGGIEDVVAKAEKLAA                               
         :                                                    
 2hld(M) : AFYMVGGIEDVVAKAEKLAA                               
           ____________________                               

Details

  Property   Value
 Conformer 1 1h48(E)
 Conformer 2 1h47(C)
 Radius gyration for conformer 1 15.16 A
 Radius gyration for conformer 2 15.15 A
 EC Number 4.6.1.12  
Click here to see the DynDom results or the famliy
 Trigger ligands C5P901
CDI421
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact No
 Spanning ligands Yes
 Residues in enzyme contacting ligands ALA33  ASP56  ASP63  ASP8  GLY58  HIS10  HIS34  HIS42  ILE57  LEU76  LYS59  PHE61  PRO62  SER35 
 Residues in extended bending regions contacting ligands ASP56  GLY58  ILE57  LEU76  LYS59  PHE61 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands ASP56  ILE57  PHE61 
  Residues in extended bending regions with an H-bond between its main chain and ligands ILE57  PHE61 
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT