3-DEOXY-MANNO-OCTULOSONATE CYTIDYLYLTRANSFERA
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1gqc(A) : SKAVIVIPARYGSSRLPGKPLLDIVGKPMIQHVYERALQVAGVAEVWVAT 
         :                                                    
 1h7h(B) : SKAVIVIPARYGSSRLPGKPLLDIVGKPMIQHVYERALQVAGVAEVWVAT 
           __________________________________________________ 

           __________________________________________________ 
 1gqc(A) : DDPRVEQAVQAFGGKAIMTRNDHESGTDRLVEVMHKVEADIYINLQGDEP 
         :                                                    
 1h7h(B) : DDPRVEQAVQAFGGKAIMTRNDHESGTDRLVEVMHKVEADIYINLQGDEP 
           __________________________________________________ 

           ______109_113_____121_____________________________ 
 1gqc(A) : MIRPRDVETLLQGMRDDPALPVATLCHAISAAEAAEPSTVKVVVNTRQDA 
         :                                                    
 1h7h(B) : MIRPRDVETLLQGMRDDPALPVATLCHAISAAEAAEPSTVKVVVNTRQDA 
           ______109_113_____121_____________________________ 

           _____________________174________185_______________ 
 1gqc(A) : LYFSRSPIPYPRNAEKARYLKHVGIYAYRRDVLQNYSQLPESMPEQAESL 
         :                                                    
 1h7h(B) : LYFSRSPIPYPRNAEKARYLKHVGIYAYRRDVLQNYSQLPESMPEQAESL 
           _____________________174________185_______________ 

           _________212______________________________         
 1gqc(A) : EQLRLMNAGINIRTFEVAATGPGVDTPACLEKVRALMAQELA         
         :                                                    
 1h7h(B) : EQLRLMNAGINIRTFEVAATGPGVDTPACLEKVRALMAQEL*         
           _________212______________________________         

Details

  Property   Value
 Conformer 1 1gqc(A)
 Conformer 2 1h7h(B)
 Radius gyration for conformer 1 17.49 A
 Radius gyration for conformer 2 17.88 A
 EC Number 2.7.7.38  
Click here to see the DynDom results or the famliy
 Trigger ligands CMK1244
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ARG10  ARG155  ARG79  ASP98  GLN202  GLN96  GLU201  GLU74  GLY174  GLY76  GLY97  HIS172  HIS73  LEU200  PRO8  SER199  SER75  TYR176  VAL140 
 Residues in extended bending regions contacting ligands GLY174  HIS172  TYR176 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands HIS172  TYR176 
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT