Poly(A) polymerase
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1hx1(A) : *PAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGD 
         :                                                    
 1kaz    : GPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGD 
           __________________________________________________ 

           __________________________________________________ 
 1hx1(A) : AAKNQVAMNPTNTVFDAKRLIGRRFDDAVVQSDMKHWPFMVVNDAGRPKV 
         :                                                    
 1kaz    : AAKNQVAMNPTNTVFDAERLIGRRFDDAVVQSDMKHWPFMVVNDAGRPKV 
           __________________________________________________ 

           __________________________________________________ 
 1hx1(A) : QVEYKGETKSFYPEEVSSMVLTKMKEIAEAYLGKTVTNAVVTVPAYFNDS 
         :                                                    
 1kaz    : QVEYKGETKSFYPEEVSSMVLTKMKEIAEAYLGKTVTNAVVTVPAYFNDS 
           __________________________________________________ 

           __________________________________________________ 
 1hx1(A) : QRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKVGAERNVLIFDLGGG 
         :                                                    
 1kaz    : QRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKVGAERNVLIFDLGGG 
           __________________________________________________ 

           ______________________228_________________________ 
 1hx1(A) : TFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDI 
         :                                                    
 1kaz    : TFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDI 
           ______________________228_________________________ 

           __________________________________________________ 
 1hx1(A) : SENKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFE 
         :                                                    
 1kaz    : SENKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFE 
           __________________________________________________ 

           _______313____________________336_____________352_ 
 1hx1(A) : ELNADLFRGTLDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQDF 
         :                                                    
 1kaz    : ELNADLFRGTLDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQDF 
           _______313____________________336_____________352_ 

           ____________________________                       
 1hx1(A) : FNGKELNKSINPDEAVAYGAAVQAAILS                       
         :                                                    
 1kaz    : FNGKELNKSINPDEAVAYGAAVQAAILS                       
           ____________________________                       

Details

  Property   Value
 Conformer 1 2hhp(A)
 Conformer 2 1fa0(A)
 Radius gyration for conformer 1 24.25 A
 Radius gyration for conformer 2 24.96 A
 EC Number 2.7.7.19  
Click here to see the DynDom results or the famliy
 Trigger ligands 3AT604
POP817
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact No
 Spanning ligands No
 Residues in enzyme contacting ligands ALA237  ASP100  ASP102  GLY233  GLY88  LEU211  LEU92  LYS215  SER89  SER99  THR194  TYR224  TYR87  VAL234  VAL94 
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT