Heat shock cognate 71 kDa protein
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space)	domain 2 is binding domain(fixed in space)

Sequence

__________________________________________________   1hx1(A) : *PAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGD           :                                                      1kaz    : GPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGD             __________________________________________________             __________________________________________________   1hx1(A) : AAKNQVAMNPTNTVFDAKRLIGRRFDDAVVQSDMKHWPFMVVNDAGRPKV           :                                                      1kaz    : AAKNQVAMNPTNTVFDAERLIGRRFDDAVVQSDMKHWPFMVVNDAGRPKV             __________________________________________________             __________________________________________________   1hx1(A) : QVEYKGETKSFYPEEVSSMVLTKMKEIAEAYLGKTVTNAVVTVPAYFNDS           :                                                      1kaz    : QVEYKGETKSFYPEEVSSMVLTKMKEIAEAYLGKTVTNAVVTVPAYFNDS             __________________________________________________             __________________________________________________   1hx1(A) : QRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKVGAERNVLIFDLGGG           :                                                      1kaz    : QRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKVGAERNVLIFDLGGG             __________________________________________________             ______________________228_________________________   1hx1(A) : TFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDI           :                                                      1kaz    : TFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDI             ______________________228_________________________             __________________________________________________   1hx1(A) : SENKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFE           :                                                      1kaz    : SENKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFE             __________________________________________________             _______313____________________336_____________352_   1hx1(A) : ELNADLFRGTLDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQDF           :                                                      1kaz    : ELNADLFRGTLDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQDF             _______313____________________336_____________352_             ____________________________                         1hx1(A) : FNGKELNKSINPDEAVAYGAAVQAAILS                                 :                                                      1kaz    : FNGKELNKSINPDEAVAYGAAVQAAILS                                   ____________________________

Details

Property   Value  Conformer 1 1hx1(A)  Conformer 2 1kaz( )  Radius gyration for conformer 1 21.64 A  Radius gyration for conformer 2 21.12 A  EC Number 3.6.1.3   Click here to see the DynDom results or the famliy  Trigger ligands ATP486  Trigger ligands in which conformation Conformation  2  Conformaton with trigger ligands is compact Yes  Spanning ligands Yes  Residues in enzyme contacting ligands ARG272  ARG342  ASP366  GLU231  GLU268  GLY12  GLY201  GLY202  GLY203  GLY230  GLY338  GLY339  ILE343  LYS271  SER275  SER340  THR13  THR14  THR204  TYR15   Residues in extended bending regions contacting ligands GLU231  GLY230  GLY338  GLY339  SER340   Residues in extended bending regions making H-bonds or salt-bridges with ligands GLY339    Residues in extended bending regions with an H-bond between its main chain and ligands GLY339  Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT