PANTOATE--BETA-ALANINE LIGASE
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space)	domain 2 is binding domain(fixed in space)

Sequence

__________________________________________________   1iho(B) : MLIIETLPLLRQQIRRLRMEGKRVALVPTMGNLHDGHMKLVDEAKARADV           :                                                      1iho(A) : MLIIETLPLLRQQIRRLRMEGKRVALVPTMGNLHDGHMKLVDEAKARADV             __________________________________________________             __________________________________________________   1iho(B) : VVVSIFVNPMQFDRPEDLARYPRTLQEDCEKLNKRKVDLVFAPSVKEIYP           :                                                      1iho(A) : VVVSIFVNPMQFDRPEDLARYPRTLQEDCEKLNKRKVDLVFAPSVKEIYP             __________________________________________________             __________________________________________________   1iho(B) : NGTETHTYVDVPGLSTMLEGASRPGHFRGVSTIVSKLFNLVQPDIACFGE           :                                                      1iho(A) : NGTETHTYVDVPGLSTMLEGASRPGHFRGVSTIVSKLFNLVQPDIACFGE             __________________________________________________             ______________________175_________________________   1iho(B) : KDFQQLALIRKMVADMGFDIEIVGVPIMRAKDGLALSSRNGYLTAEQRKI           :                                                      1iho(A) : KDFQQLALIRKMVADMGFDIEIVGVPIMRAKDGLALSSRNGYLTAEQRKI             ______________________175_________________________             __________________________________________________   1iho(B) : APGLYKVLSSIADKLQAGERDLDEIITIAGQELNEKGFRADDIQIRDADT           :                                                      1iho(A) : APGLYKVLSSIADKLQAGERDLDEIITIAGQELNEKGFRADDIQIRDADT             __________________________________________________             ________________________________                     1iho(B) : LLEVSETSKRAVILVAAWLGDARLIDNKMVEL                             :                                                      1iho(A) : LLEVSETSKRAVILVAAWLGDARLIDNKMVEL                               ________________________________

Details

Property   Value  Conformer 1 1iho(B)  Conformer 2 1iho(A)  Radius gyration for conformer 1 20.17 A  Radius gyration for conformer 2 20.2 A  EC Number 6.3.2.1   Click here to see the DynDom results or the famliy  Trigger ligands TRS701  Trigger ligands in which conformation Conformation  2  Conformaton with trigger ligands is compact No  Spanning ligands No  Residues in enzyme contacting ligands ALA180  ARG198  ASN190  LEU186  SER187   Residues in extended bending regions contacting ligands ALA180   Residues in extended bending regions making H-bonds or salt-bridges with ligands Null   Residues in extended bending regions with an H-bond between its main chain and ligands Null Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT