PANTOTHENATE KINASE
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space)	domain 2 is binding domain(fixed in space)

Sequence

__________________________________________________   1esm(B) : **LtPYLQFDRNQWAALRDSVPtLSEDEIARLKGINEDLSLEEVAEIYLP           :                                                      1esn(A) : QTLtPYLQFDRNQWAALRDSVPtLSEDEIARLKGINEDLSLEEVAEIYLP             __________________________________________________             _____64______________________88___________________   1esm(B) : LSRLLNFYISSNLRRQAVLEQFLGTNGQRIPYIISIAGSVAVGKSTTARV           :                                                      1esn(A) : LSRLLNFYISSNLRRQAVLEQFLGTNGQRIPYIISIAGSVAVGKSTTARV             _____64______________________88___________________             __________________________________________________   1esm(B) : LQALLSRWPEHRRVELITTDGFLHPNQVLKERGLkKKGFPESYDhRLVKF           :                                                      1esn(A) : LQALLSRWPEHRRVELITTDGFLHPNQVLKERGLkKKGFPESYDhRLVKF             __________________________________________________             __________________________________________________   1esm(B) : VSDLKSGVPNVTAPVYSHLIYDVIPDGDKTVVQPDILILEGLNVLQSGdY           :                                                      1esn(A) : VSDLKSGVPNVTAPVYSHLIYDVIPDGDKTVVQPDILILEGLNVLQSGdY             __________________________________________________             __________________________________________________   1esm(B) : --dPHHVFVSDFVDFSIYVDAPEDLLQTWYINRFLKFREGAFTDPDSYFH           :                                                      1esn(A) : PHDPHHVFVSDFVDFSIYVDAPEDLLQTWYINRFLKFREGAFTDPDSYFH             __________________________________________________             __________________________________________________   1esm(B) : NYAKLTKEEAIKTAtLWKEINWLNLKQNILPTRERASLILTKSANHAVEE           :                                                      1esn(A) : NYAKLTKEEAIKTAtLWKEINWLNLKQNILPTRERASLILTKSANHAVEE             __________________________________________________             _____                                                1esm(B) : VRLRK                                                        :                                                      1esn(A) : VRLRK                                                          _____

Details

Property   Value  Conformer 1 1esm(B)  Conformer 2 1esn(A)  Radius gyration for conformer 1 19.62 A  Radius gyration for conformer 2 20.01 A  EC Number 2.7.1.33   Click here to see the DynDom results or the famliy  Trigger ligands ANP401  Trigger ligands in which conformation Conformation  2  Conformaton with trigger ligands is compact No  Spanning ligands No  Residues in enzyme contacting ligands ALA98  ARG243  ASN43  ASP45  GLU199  GLY100  HIS307  LEU46  LYS101  LYS303  SER102  THR103  TYR55  VAL97  VAL99   Residues in extended bending regions contacting ligands Null  Residues in extended bending regions making H-bonds or salt-bridges with ligands Null   Residues in extended bending regions with an H-bond between its main chain and ligands Null Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT