R-alcohol dehydrogenase
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space)	domain 2 is binding domain(fixed in space)

Sequence

__________________________________________________   1zk3(C) : SNRLDGKVAIITGGTLGIGLAIATKFVEEGAKVMITDRHSDVGEKAAKSV           :                                                      1zk4(A) : SNRLDGKVAIITGGTLGIGLAIATKFVEEGAKVMITGRHSDVGEKAAKSV             __________________________________________________             __________________________________________________   1zk3(C) : GTPDQIQFFQHDSSDEDGWTKLFDATEKAFGPVSTLVNNAGIAVNKSVEE           :                                                      1zk4(A) : GTPDQIQFFQHDSSDEDGWTKLFDATEKAFGPVSTLVNNAGIAVNKSVEE             __________________________________________________             __________________________________________________   1zk3(C) : TTTAEWRKLLAVNLDGVFFGTRLGIQRMKNKGLGASIINMSSIEGFVGDP           :                                                      1zk4(A) : TTTAEWRKLLAVNLDGVFFGTRLGIQRMKNKGLGASIINMSSIEGFVGDP             __________________________________________________             ________________________________185_______________   1zk3(C) : SLGAYNASKGAVRIMSKSAALDCALKDYDVRVNTVHPGYIKTPLVDDLPG           :                                                      1zk4(A) : SLGAYNASKGAVRIMSKSAALDCALKDYDVRVNTVHPGYIKTPLVDDLPG             ________________________________185_______________             ____207___________________________________________   1zk3(C) : AEEAMSQRTKTPMGHIGEPNDIAYICVYLASNESKFATGSEFVVDGGYTA           :                                                      1zk4(A) : AEEAMSQRTKTPMGHIGEPNDIAYICVYLASNESKFATGSEFVVDGGYTA             ____207___________________________________________             _                                                    1zk3(C) : Q                                                            :                                                      1zk4(A) : Q                                                              _

Details

Property   Value  Conformer 1 1zk3(C)  Conformer 2 1zk4(A)  Radius gyration for conformer 1 17.34 A  Radius gyration for conformer 2 17.48 A  EC Number 1.1.1.2   Click here to see the DynDom results or the famliy  Trigger ligands NAP1270  Trigger ligands in which conformation Conformation  2  Conformaton with trigger ligands is compact No  Spanning ligands Yes  Residues in enzyme contacting ligands ALA90  ARG38  ASN89  ASP62  GLY13  GLY14  GLY17  GLY188  GLY19  GLY37  GLY91  HIS61  ILE18  ILE190  ILE92  LEU16  LEU194  MET140  SER63  THR15  THR192  THR36  TYR155  VAL112  VAL195   Residues in extended bending regions contacting ligands GLY188  ILE190  THR192   Residues in extended bending regions making H-bonds or salt-bridges with ligands ILE190    Residues in extended bending regions with an H-bond between its main chain and ligands ILE190  Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT