tyrosyl-tRNA synthetase
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space)	domain 2 is binding domain(fixed in space)

Sequence

__________________________________________________   1n3l(A) : APSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYF           :                                                      1q11(A) : APSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYF             __________________________________________________             __________________73___________________94_________   1n3l(A) : VPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKA           :                                                      1q11(A) : VPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKA             __________________73___________________94_________             __________________________________________________   1n3l(A) : MLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVV           :                                                      1q11(A) : MLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVV             __________________________________________________             __________________________________________________   1n3l(A) : KQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPALG           :                                                      1q11(A) : KQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPALG             __________________________________________________             __________________________________________________   1n3l(A) : YSKRVHLMNPMVPGLTGSeSKIDLLDRKEDVKKKLKKAFCEPGNVENNGV           :                                                      1q11(A) : YSKRVHLMNPMVPGLTG---kIDLLDRKEDVKKKLKKAFCEPGNVENNGV             __________________________________________________             __________________________________________________   1n3l(A) : LSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLK           :                                                      1q11(A) : LSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLK             __________________________________________________             ______________327_______________                     1n3l(A) : NSVEVALNKLLDPIREKFNTPALKKLASAAYP                             :                                                      1q11(A) : NSVEVALNKLLDPIREKFNTPALKKLASAAYP                               ______________327_______________

Details

Property   Value  Conformer 1 1n3l(A)  Conformer 2 1q11(A)  Radius gyration for conformer 1 21.19 A  Radius gyration for conformer 2 21 A  EC Number 6.1.1.1   Click here to see the DynDom results or the famliy  Trigger ligands TYB401  Trigger ligands in which conformation Conformation  2  Conformaton with trigger ligands is compact Yes  Spanning ligands Yes  Residues in enzyme contacting ligands ALA43  ALA74  ASP173  GLN170  GLN182  GLN188  GLY41  HIS77  LEU72  TYR166  TYR39  VAL152   Residues in extended bending regions contacting ligands ALA74  HIS77  LEU72   Residues in extended bending regions making H-bonds or salt-bridges with ligands Null   Residues in extended bending regions with an H-bond between its main chain and ligands Null Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT